| Date | Time | Preseason | Final |
| Sunday, Sep. 25 | 2:00 pm | at Washington Capitals | BUF 4, WSH 3 OT |
| Tuesday, Sept. 27 | 7:00 pm | vs. Philadelphia Flyers | BUF 2, PHI 1 |
| Wednesday, Sep. 28 | 7:00 pm | at Columbus Blue Jackets | CBJ 4, BUF 1 |
| Saturday, Oct. 01 | 1:00 pm | vs. Pittsburgh Penguins | BUF 3, PIT 1 |
| Tuesday, Oct. 04 | 7:00 pm | vs. Carolina Hurricanes | BUF 4, CAR 2 |
| Friday, Oct. 07 | 7:00 pm | at Pittsburgh Penguins | PIT 7, BUF 1 |
| Date | Time | October 2022 | Final |
| Thursday, Oct. 13 | 7:00 pm | vs. Ottawa Senators | BUF 4, OTT 1 |
| Saturday, Oct. 15 | 1:00 pm | vs. Florida Panthers | FLA 4, BUF 3 |
| Tuesday, Oct. 18 | 9:00 pm | at Edmonton Oilers | BUF 4, EDM 2 |
| Thursday, Oct. 20 | 9:00 pm | at Calgary Flames | BUF 6, CGY 3 |
| Saturday, Oct. 22 | 10:00 pm | at Vancouver Canucks | BUF 5, VAN 1 |
| Tuesday, Oct. 25 | 10:00 pm | at Seattle Kraken | SEA 5, BUF 1 |
| Thursday, Oct. 27 | 7:00 pm | vs. Montreal Canadiens | MTL 3, BUF 2 |
| Saturday, Oct. 29 | 7:00 pm | vs. Chicago Blackhawks | BUF 4, CHI 3 OT |
| Monday, Oct. 31 | 7:00 pm | vs. Detroit Red Wings | BUF 8, DET 3 |
| Date | Time | November 2022 | Final |
| Wednesday, Nov. 02 | 7:30 pm | vs. Pittsburgh Penguins | BUF 6, PIT 3 |
| Friday, Nov. 04 | 7:00 pm | at Carolina Hurricanes | CAR 5, BUF 3 |
| Saturday, Nov. 05 | 7:00 pm | at Tampa Bay Lightning | TBL 5, BUF 3 |
| Tuesday, Nov. 08 | 7:00 pm | vs. Arizona Coyotes | ARI 4, BUF 1 |
| Thursday, Nov. 10 | 7:00 pm | vs. Vegas Golden Knights | VGK 7, BUF 4 |
| Saturday, Nov. 12 | 7:00 pm | vs. Boston Bruins | BOS 3, BUF 1 |
| Tuesday, Nov. 15 | 7:00 pm | vs. Vancouver Canucks | VAN 5, BUF 4 |
| Wednesday, Nov. 16 | 7:00 pm | at Ottawa Senators | OTT 4, BUF 1 |
| Saturday, Nov. 19 | 7:00 pm | at Toronto Maple Leafs | TOR 5, BUF 2 |
| Tuesday, Nov. 22 | 7:00 pm | at Montreal Canadiens | BUF 7, MON 2 |
| Wednesday, Nov. 23 | 7:00 pm | vs. St. Louis Blues | BUF 6, STL 2 |
| Friday, Nov. 25 | 7:30 pm | vs. New Jersey Devils | NJD 3, BUF 1 |
| Monday, Nov. 28 | 7:00 pm | vs. Tampa Bay Lightning | TBL 6, BUF 5 OT |
| Wednesday, Nov. 30 | 7:00 pm | at Detroit Red Wings | BUF 5, DET 4 SO |
| Date | Time | December 2022 | Final |
| Thursday, Dec. 01 | 7:00 pm | vs. Colorado Avalanche | COL 6, BUF 4 |
| Sunday, Dec. 04 | 7:00 pm | vs. San Jose Sharks | BUF 6, SJS 3 |
| Wednesday, Dec. 07 | 7:00 pm | at Columbus Blue Jackets | BUF 9, CBJ 4 |
| Friday, Dec. 09 | 7:00 pm | vs. Pittsburgh Penguins | PIT 4, BUF 3 OT |
| Saturday, Dec. 10 | 7:00 pm | at Pittsburgh Penguins | PIT 3, BUF 1 |
| Tuesday, Dec. 13 | 7:00 pm | vs. Los Angeles Kings | BUF 6, LAK 0 |
| Thursday, Dec. 15 | 9:00 pm | at Colorado Avalanche | BUF 4, COL 2 |
| Saturday, Dec. 17 | 9:00 pm | at Arizona Coyotes | BUF 5, ARI 2 |
| Monday, Dec. 19 | 10:00 pm | at Vegas Golden Knights | BUF 3, VGK 2 |
| Thursday, Dec. 29 | 7:00 pm | vs. Detroit Red Wings | BUF 6, DET 3 |
| Saturday, Dec. 31 | 1:00 pm | at Boston Bruins | BUF 4, BOS 3 OT |
| Date | Time | January 2023 | Final |
| Sunday, Jan. 01 | 7:00 pm | at Ottawa Senators | OTT 3, BUF 1 |
| Tuesday, Jan. 03 | 7:00 pm | at Washington Capitals | BUF 5, WSH 4 OT |
| Saturday, Jan. 07 | 7:00 pm | vs. Minnesota Wild | BUF 6, MIN 5 OT |
| Monday, Jan. 09 | 7:00 pm | vs. Philadelphia Flyers | PHI 4, BUF 0 |
| Tuesday, Jan. 10 | 7:00 pm | vs. Seattle Kraken | SEA 4, BUF 3 |
| Thursday, Jan. 12 | 7:00 pm | vs. Winnipeg Jets | WPG 4, BUF 2 |
| Saturday, Jan. 14 | 8:00 pm | at Nashville Predators | BUF 5, NSH 3 |
| Monday, Jan. 16 | 1:00 pm | vs. Florida Panthers | FLA 4, BUF 1 |
| Tuesday, Jan. 17 | 8:30 pm | at Chicago Blackhawks | CHI 4, BUF 3 OT |
| Thursday, Jan. 19 | 7:00 pm | vs. New York Islanders | BUF 3, NYI 2 OT |
| Saturday, Jan. 21 | 12:30 pm | vs. Anaheim Ducks | BUF 6, ANA 3 |
| Monday, Jan. 23 | 8:30 pm | at Dallas Stars | BUF 3, DAL 2 OT |
| Tuesday, Jan. 24 | 8:00 pm | at St. Louis Blues | BUF 5, STL 3 |
| Thursday, Jan. 26 | 8:00 pm | at Winnipeg Jets | BUF 3, WPG 2 |
| Saturday, Jan. 28 | 9:00 pm | at Minnesota Wild | MIN 3, BUF 2 OT |
| Date | Time | February 2023 | Final |
| Wednesday, Feb. 01 | 7:30 pm | vs. Carolina Hurricanes | CAR 5, BUF 1 |
| Saturday, Feb. 11 | 12:30 pm | vs. Calgary Flames | CGY 7, BUF 2 |
| Monday, Feb. 13 | 10:30 pm | at Los Angeles Kings | LAK 5, BUF 2 |
| Wednesday, Feb. 15 | 10:00 pm | at Anaheim Ducks | BUF 7, ANA 3 |
| Saturday, Feb. 18 | 10:30 pm | at San Jose Sharks | BUF 4, SJS 2 |
| Tuesday, Feb. 21 | 7:30 pm | vs. Toronto Maple Leafs | TOR 6, BUF 3 |
| Thursday, Feb. 23 | 7:00 pm | at Tampa Bay Lightning | BUF 6, TBL 5 OT |
| Friday, Feb. 24 | 7:00 pm | at Florida Panthers | BUF 3, FLA 1 |
| Sunday, Feb. 26 | 1:00 pm | vs. Washington Capitals | BUF 7, WSH 4 |
| Tuesday, Feb. 28 | 1:00 pm | vs. Columbus Blue Jackets | CBJ 5, BUF 3 |
| Date | Time | March 2023 | Final |
| Thursday, Mar. 02 | 7:00 pm | at Boston Bruins | BOS 7, BUF 1 |
| Saturday, Mar. 04 | 12:30 pm | vs. Tampa Bay Lightning | BUF 5, TBL 3 |
| Monday, Mar. 06 | 7:30 pm | vs. Edmonton Oilers | EDM 3, BUF 2 |
| Tuesday, Mar. 07 | 7:30 pm | at New York Islanders | NYI 3, BUF 2 |
| Thursday, Mar. 09 | 7:00 pm | vs. Dallas Stars | DAL 10, BUF 4 |
| Saturday, Mar. 11 | 5:00 pm | vs. New York Rangers | NYR 2, BUF 1 OT |
| Monday, Mar. 13 | 7:30 pm | at Toronto Maple Leafs | BUF 6, TOR 3 |
| Wednesday, Mar. 15 | 7:00 pm | at Washington Capitals | WSH 5, BUF 4 SO |
| Friday, Mar. 17 | 7:00 pm | at Philadelphia Flyers | PHI 5, BUF 2 |
| Sunday, Mar. 19 | 1:00 pm | vs. Boston Bruins | BOS 7, BUF 0 |
| Tuesday, Mar. 21 | 7:00 pm | vs. Nashville Predators | NSH 7, BUF 3 |
| Friday, Mar. 24 | 7:00 pm | vs. New Jersey Devils | BUF 5, NJD 4 |
| Saturday, Mar. 25 | 5:30 pm | at New York Islanders | BUF 2, NYI 0 |
| Monday, Mar. 27 | 7:00 pm | vs. Montreal Canadiens | MON 4, BUF 3 SO |
| Friday, Mar. 31 | 7:00 pm | vs. New York Rangers | BUF 3, NYR 2 OT |
| Date | Time | April 2023 | Final |
| Saturday, Apr 01 | 7:00 pm | at Philadelphia Flyers | BUF 6, PHI 3 |
| Tuesday, Apr 04 | 7:00 pm | at Florida Panthers | FLA 2, BUF 1 |
| Thursday, Apr 06 | 7:30 pm | at Detroit Red Wings | BUF 7, DET 6 SO |
| Saturday, Apr 08 | 12:30 pm | vs. Carolina Hurricanes | BUF 4, CAR 3 |
| Monday, Apr 10 | 7:00 pm | at New York Rangers | BUF 3, NYR 2 SO |
| Tuesday, Apr 11 | 7:00 pm | at New Jersey Devils | NJD 6, BUF 2 |
| Thursday, Apr 13 | 7:00 pm | vs. Ottawa Senators | BUF 4, OTT 3 OT |
| Friday, Apr. 14 | 7:00 pm | at Columbus Blue Jackets | BUF 5, CBJ 2 |